HORDB

ID: hor005162
Uniprot ID: P09684
Protein name: Vasoactive intestinal peptide
Gene name: vip
Organism: Gadus morhua (Atlantic cod)
Family: Glucagon family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Gadus (genus), Gadidae (family), Gadoidei (suborder), Gadiformes (order), Gadariae, Zeiogadaria, Paracanthopterygii, Acanthomorphata, Ctenosquamata, Eurypterygia, Neoteleostei, Euteleosteomorpha (cohort), Clupeocephala, Osteoglossocephalai, Teleostei (infraclass), Neopterygii (subclass), Actinopteri (class), Actinopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007165 signal transduction; GO:0048255 mRNA stabilization; GO:0070459 prolactin secretion
GO CC: GO:0005576 extracellular region

Function: VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

AF-P09684-F1.pdb

hor005162_AF2.pdb

hor005162_ESM.pdb

Mass:	340659	Formula:	C131H201N39O39S
Absent amino acids:	CEGIPW	Common amino acids:	AKS
pI:	10.32	Basic residues:	6
Polar residues:	8	Hydrophobic residues:	7
Hydrophobicity:	-104.8	Boman Index:	-7776
Half-Life:	3.5 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	39.2
Instability Index:	3135.2	Extinction Coefficient cystines:	2980
Absorbance 280nm:	124.17